PUBLICATIONS
Panagaki D, Croft JT, Keuenhof K, Larsson Berglund L, Andersson S, Kohler V, Büttner S, Tamás MJ, Nyström T, Neutze R, Höög JL. Nuclear envelope budding is a response to cellular stress. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2020997118. doi: 10.1073/pnas.2020997118. PMID: 34290138
Keuenhof KS, Berglund LL, Hill SM, Schneider KL, Widlund PO, Nyström T, Höög JL. Large organellar changes occur during mild heat shock in yeast. J Cell Sci. 2021 Jul 7:jcs.258325. doi: 10.1242/jcs.258325. Epub ahead of print. PMID: 34232988.
Eisele F, Eisele-Bürger AM, Hao X, Berglund LL, Höög JL, Liu B, Nyström T. An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality control. Cell Rep. 2021 Jun 29;35(13):109328. doi: 10.1016/j.celrep.2021.109328. PMID: 34192536.
Schneider KL, Wollman AJM, Nyström T, Shashkova S. Comparison of endogenously expressed fluorescent protein fusions behaviour for protein quality control and cellular ageing research. Sci Rep. 2021 Jun 17;11(1):12819. doi: 10.1038/s41598-021-92249-1. PMID: 34140587
Andersson S, Romero A, Rodrigues JI, Hua S, Hao X, Jacobson T, Karl V, Becker N, Ashouri A, Rauch S, Nyström T, Liu B, Tamás MJ. Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity. J Cell Sci. 2021 Jun 1;134(11):jcs258338. doi: 10.1242/jcs.258338. Epub 2021 Jun 4. Pubmed PMID: 34085697
Andersson R, Eisele-Bürger AM, Hanzén S, Vielfort K, Öling D, Eisele F, Johansson G, Gustafsson T, Kvint K, Nyström T. Differential role of cytosolic Hsp70s in longevity assurance and protein quality control. PLoS Genet [Internet]. 2021 Jan 11;17(1):e1008951. PubMed PMID: 33428620
Shashkova S, Nyström T, Leake MC, Wollman AJM. Correlative single-molecule fluorescence barcoding of gene regulation in Saccharomyces cerevisiae. Methods. 2020 Oct 18. doi: 10.1016/j.ymeth.2020.10.009. PubMed PMID: 33086048
Babazadeh R, Ahmadpour D, Nyström T. Hitchhiking on vesicles: a way to harness age-related
proteopathies? FEBS J. 2020 Apr 26. doi: 10.1111/febs.15345 PubMed PMID: 32336030
Chen X, Ji B, Hao X, Li X, Eisele F, Nyström T, Petranovic D. FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism. Nat. Commun. 2020. 11, 1–16. doi:10.1038/s41467-020-14525-4 PubMed PMID: 32054832
Babazadeh R, Ahmadpour D, Jia S, Hao X, Widlund P, Schneider K, Eisele F, Dolz Edo L, Smits GJ, Liu B, Nyström T. Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress. Cell Rep. 2019 Aug 20;28: e8 2096-2110. doi: 10.1016/j.cellrep.2019.07.053 PubMed PMID: 31433985
Schneider KL, Nyström T, Widlund PO. Studying Spatial Protein Quality Control, Proteopathies, and Aging Using Different Model Misfolding Proteins in S. cerevisiae. Front Mol Neurosci. 2018;11(July):1–13.
Suhm T, Kaimal JM, Dawitz H, Peselj C, Masser AE, Hanzén S, Ambrožič M, Smialowska A, Björck ML, Brzezinski P, Nyström T, Büttner S, Andréasson C, Ott M. Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis. Cell Metab. 2018 Jun 5;27(6):1309-1322.e6. doi: 10.1016/j.cmet.2018.04.011. PubMed PMID: 29754951
Berglund LL, Hao X, Liu B, Grantham J, Nyström T. Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast. Sci Rep. 2017 Sep 12;7(1):11328. doi: 10.1038/s41598-017-11102-6. PubMed PMID: 28900136
Josefson R, Andersson R, Nyström T. How and why do toxic conformers of aberrant proteins accumulate during ageing? Essays Biochem. 2017 May 24. pii: EBC20160085. doi: 10.1042/EBC20160085. [Epub ahead of print] PubMed PMID: 28539486
Gottschling DE, and Nyström T. The Upsides and Downsides of Organelle Interconnectivity. Cell. 2017.169(1), pp.24–34. doi: 10.1016/j.cell.2017.02.030. PubMed PMID: 28340346
Hill SM, Hanzén S, and Nyström T. Restricted access: spatial sequestration of damaged proteins during stress and aging. EMBO Reports. 2017. Feb 13; e201643458. doi: 10.15252/embr.201643458. PubMed PMID: 28193623
Zhao L, Yang Q, Zheng J, Zhu X, Hao X, Song J, Lebacq T, Franssens V, Winderickx J, Nystrom T, Liu B. A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae. Scientific Reports. 2016 Jul 21;6:30134. doi: 10.1038/srep30134. PubMed PMID: 27440388
Hill SM, Hao X, Grönvall J, Spikings-Nordby S, Widlund PO, Amen T, Jörhov A, Josefson R, Kaganovich D, Liu B, Nyström T. Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions. Cell Reports. 2016. Jul 19;16(3):826-38. doi: 10.1016/j.celrep.2016.06.016. PubMed PMID: 27373154
Hanzén S, Vielfort K, Yang J, Roger F, Andersson V, Zamarbide-Forés S, Andersson R, Malm L, Palais G, Biteau B, Liu B, Toledano MB, Molin M, Nyström T. Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins. Cell. 2016 Jun 30;166(1): 140-51. doi: 10.1016/j.cell.2016.05.006. Epub 2016 Jun 2. PubMed PMID: 27264606
Malmgren Hill S, Nyström T. Selective protein degradation ensures cellular longevity.
Elife. 2016 Jun 1;5. pii: e17185. doi: 10.7554/eLife.17185.PubMed PMID: 27247277
Yang J, Hao X, Cao X, Liu B, Nyström T. Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex. Elife. 2016. Apr 1;5. pii: e11792. doi: 10.7554/eLife.11792. PubMed PMID: 27033550.
Hill SM, Nyström T. The dual role of a yeast metacaspase: What doesn't kill you makes you stronger. Bioessays. 2015 May;37(5):525-31. doi:10.1002/bies.201400208. Epub 2015 Feb 13. PubMed PMID: 25677381.
Yang X, Shen Y, Garre E, Hao X, Krumlinde D, Cvijović M, Arens C, Nyström T, Liu B, Sunnerhagen P. Stress granule-defective mutants deregulate stress responsive transcripts. PLoS Genet. 2014 Nov 6;10(11):e1004763. doi: 10.1371/journal.pgen.1004763. eCollection 2014 Nov. PubMed PMID: 25375155; PubMed Central PMCID: PMC4222700.
Song J, Yang Q, Yang J, Larsson L, Hao X, Zhu X, Malmgren-Hill S, Cvijovic M, Fernandez-Rodriguez J, Grantham J, Gustafsson CM, Liu B, Nyström T. Essential genetic interactors of SIR2 required for spatial sequestration and asymmetrical inheritance of protein aggregates. PLoS Genet. 2014 Jul 31;10(7):e1004539. doi: 10.1371/journal.pgen.1004539. eCollection 2014 Jul. PubMed PMID: 25079602; PubMedCentral PMCID: PMC4117435.
Hill SM, Hao X, Liu B, Nyström T. Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae. Science. 2014 Jun 20;344(6190):1389-92.
doi:10.1126/science.1252634. Epub 2014 May 22. PubMed PMID: 24855027.
Nyström T, Liu B. The mystery of aging and rejuvenation - a budding topic. Curr Opin Microbiol. 2014 Apr;18:61-7. doi: 10.1016/j.mib.2014.02.003. Epub 2014 Mar 12. Review. PubMed PMID: 24631930.
Öling D, Eisele F, Kvint K, Nyström T. Opposing roles of Ubp3-dependent deubiquitination regulate replicative life span and heat resistance. EMBO J. 2014. Apr 1;33(7):747-61. doi: 10.1002/embj.201386822. Epub 2014 Mar 4. PubMed PMID:24596250; PubMed Central PMCID: PMC4000091.
Dillin A, Gottschling DE, Nyström T. The good and the bad of being connected: the integrons of aging. Curr Opin Cell Biol. 2014 Feb;26:107-12. doi:10.1016/j.ceb.2013.12.003. Epub 2013 Dec 30. Review. PubMed PMID: 24529252;PubMed Central PMCID: PMC3927154.
Nyström T, Liu B. Protein quality control in time and space - links to cellular aging. FEMS Yeast Res. 2014 Feb;14(1):40-8. doi:10.1111/1567-1364.12095. Epub 2013 Oct 11. Review. PubMed PMID: 24103195.
Nyström T. Aging: filtering out bad mitochondria. Curr Biol. 2013 Dec 2;23(23):R1037-9. doi:10.1016/j.cub.2013.10.049. PubMed PMID: 24309277.
Andersson V, Hanzén S, Liu B, Molin M, Nyström T. Enhancing protein disaggregation restores proteasome activity in aged cells. Aging (Albany NY). 2013 Nov;5(11):802-12. PubMed PMID: 24243762; PubMed Central PMCID: PMC3868723.
Erjavec N, Bayot A, Gareil M, Camougrand N, Nystrom T, Friguet B, Bulteau AL. Deletion of the mitochondrial Pim1/Lon protease in yeast results in accelerated aging and impairment of the proteasome. Free Radic Biol Med. 2013 Mar;56:9-16.
doi: 10.1016/j.freeradbiomed.2012.11.019. Epub 2012 Dec 5. PubMed PMID: 23220263.
Hernebring M, Fredriksson Å, Liljevald M, Cvijovic M, Norrman K, Wiseman J, Semb H,
Nyström T. Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28. Sci Rep. 2013;3:1381. doi:10.1038/srep01381. PubMed PMID: 23459332; PubMed Central PMCID: PMC3587881.
Carlsten JO, Szilagyi Z, Liu B, Lopez MD, Szászi E, Djupedal I, Nyström T, Ekwall K, Gustafsson CM, Zhu X. Mediator promotes CENP-a incorporation at fission yeast centromeres. Mol Cell Biol. 2012 Oct;32(19):4035-43. doi:10.1128/MCB.00374-12. Epub 2012 Jul 30. Erratum in: Mol Cell Biol. 2012. Dec;32(24):5151. PubMed PMID: 22851695; PubMed Central PMCID: PMC3457525.
Nyström T, Yang J, Molin M. Peroxiredoxins, gerontogenes linking aging to genome instability and cancer. Genes Dev. 2012 Sep 15;26(18):2001-8. doi:10.1101/gad.200006.112. Review. PubMed PMID: 22987634; PubMed Central PMCID: PMC3444726.
Fredriksson Å, Johansson Krogh E, Hernebring M, Pettersson E, Javadi A, Almstedt A,
Nyström T. Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster. Aging Cell. 2012 Aug;11(4):634-43.
doi:10.1111/j.1474-9726.2012.00823.x. Epub 2012 May 21. PubMed PMID: 22507075.
Breitenbach M, Laun P, Dickinson JR, Klocker A, Rinnerthaler M, Dawes IW, Aung-Htut MT, Breitenbach-Koller L, Caballero A, Nyström T, Büttner S, Eisenberg T, Madeo F, Ralser M.
The role of mitochondria in the aging processes of yeast. Subcell Biochem. 2012;57:55-78. doi: 10.1007/978-94-007-2561-4_3. Review. PubMed PMID: 22094417.
Liu B, Larsson L, Franssens V, Hao X, Hill SM, Andersson V, Höglund D, Song J, Yang X, Öling D, Grantham J, Winderickx J, Nyström T. Segregation of protein aggregates involves actin and the polarity machinery. Cell. 2011 Nov 23;147(5):959-61. doi:10.1016/j.cell.2011.11.018. PubMed PMID: 22118450.
Molin M, Yang J, Hanzén S, Toledano MB, Labarre J, Nyström T. Life span extension and H(2)O(2) resistance elicited by caloric restriction require the peroxiredoxin Tsa1 in Saccharomyces cerevisiae. Mol Cell. 2011 Sep 2;43(5):823-33.
doi: 10.1016/j.molcel.2011.07.027. PubMed PMID: 21884982.
Zhu X, Liu B, Carlsten JO, Beve J, Nyström T, Myers LC, Gustafsson CM. Mediator influences telomeric silencing and cellular life span. Mol Cell Biol. 2011 Jun;31(12):2413-21.
doi:10.1128/MCB.05242-11. Epub 2011 Apr 11. PubMed PMID: 21482672; PubMed Central PMCID: PMC3133415.
Caballero A, Ugidos A, Liu B, Öling D, Kvint K, Hao X, Mignat C, Nachin L, Molin M, Nyström T. Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing. Mol Cell. 2011 May 6;42(3):390-400. doi:10.1016/j.molcel.2011.03.021. PubMed PMID: 21549315.
Nyström T. Spatial protein quality control and the evolution of lineage-specific ageing. Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):71-5. doi: 10.1098/rstb.2010.0282. Review. PubMed PMID: 21115532; PubMed Central PMCID: PMC3001311.
Persson O, Nyström T, Farewell A. UspB, a member of the sigma-S regulon, facilitates RuvC resolvase function. DNA Repair (Amst). 2010 Nov 10;9(11):1162-9.
doi:10.1016/j.dnarep.2010.08.004. PubMed PMID: 20817623.
Ugidos A, Nyström T, Caballero A. Perspectives on the mitochondrial etiology of replicative aging in yeast. Exp Gerontol. 2010 Aug;45(7-8):512-5. doi:10.1016/j.exger.2010.02.002. Epub 2010 Feb 12. Review. PubMed PMID: 20153818.
Orlandi I, Bettiga M, Alberghina L, Nyström T, Vai M. Sir2-dependent asymmetric segregation of damaged proteins in ubp10 null mutants is independent of genomic silencing.
Biochim Biophys Acta. 2010 May;1803(5):630-8. doi:10.1016/j.bbamcr.2010.02.009. Epub 2010 Mar 4. PubMed PMID: 20211662.
Liu B, Larsson L, Caballero A, Hao X, Oling D, Grantham J, Nyström T. The polarisome is required for segregation and retrograde transport of protein aggregates. Cell. 2010 Jan 22;140(2):257-67. doi: 10.1016/j.cell.2009.12.031. PubMed PMID: 20141839.
Erjavec N, Cvijovic M, Klipp E, Nyström T. Selective benefits of damage partitioning in unicellular systems and its effects on aging. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18764-9. doi:10.1073/pnas.0804550105. Epub 2008 Nov 19. PubMed PMID: 19020097; PubMed Central PMCID: PMC2596250.
Nachin L, Brive L, Persson KC, Svensson P, Nyström T. Heterodimer formation within universal stress protein classes revealed by an in silico and experimental approach. J Mol Biol. 2008 Jul 4;380(2):340-50. doi: 10.1016/j.jmb.2008.04.074. Epub 2008 May 7. PubMed PMID: 18514734.
Hlavatá L, Nachin L, Jezek P, Nyström T. Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes. Aging Cell. 2008. Mar;7(2):148-57. Epub 2007 Dec 10. PubMed PMID: 18081742.
Nyström T. A bacterial kind of aging. PLoS Genet. 2007 Dec;3(12):e224. PubMed
PMID: 18085827; PubMed Central PMCID: PMC2134940.
Erjavec N, Larsson L, Grantham J, Nyström T. Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. Genes Dev. 2007 Oct 1;21(19):2410-21. PubMed PMID: 17908928; PubMed Central PMCID: PMC1993872.
Stojnev T, Harichová J, Ferianc P, Nyström T. Function of a novel cadmium-induced yodA protein in Escherichia coli. Curr Microbiol. 2007. Aug;55(2):99-104. Epub 2007 Jul 11. PubMed PMID: 17632755.
Persson O, Valadi A, Nyström T, Farewell A. Metabolic control of the Escherichia coli universal stress protein response through fructose-6-phosphate. Mol Microbiol. 2007 Aug;65(4):968-78. Epub 2007 Jul 19. PubMed PMID: 17640273.
Magnusson LU, Gummesson B, Joksimović P, Farewell A, Nyström T. Identical, independent, and opposing roles of ppGpp and DksA in Escherichia coli. J. Bacteriol. 2007 Jul;189(14):5193-202. Epub 2007 May 11. PubMed PMID: 17496080; PubMed Central PMCID: PMC1951846.
Erjavec N, Nyström T. Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10877-81. Epub 2007 Jun 20. PubMed PMID: 17581878; PubMed Central PMCID: PMC1904135.
Eriksson E, Enger J, Nordlander B, Erjavec N, Ramser K, Goksör M, Hohmann S, Nyström T, Hanstorp D. A microfluidic system in combination with optical tweezers for analyzing rapid and reversible cytological alterations in single cells upon environmental changes. Lab Chip. 2007 Jan;7(1):71-6. Epub 2006 Oct 4. PubMed PMID: 17180207.
Scheckhuber CQ, Erjavec N, Tinazli A, Hamann A, Nyström T, Osiewacz HD. Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat Cell Biol. 2007 Jan;9(1):99-105. Epub 2006 Dec 7. PubMed PMID: 17173038.
Fredriksson A, Nyström T. Conditional and replicative senescence in Escherichia coli. Curr Opin Microbiol. 2006 Dec;9(6):612-8. Epub 2006 Oct 25. Review. PubMed PMID: 17067847.
Hernebring M, Brolén G, Aguilaniu H, Semb H, Nyström T. Elimination of damaged proteins during differentiation of embryonic stem cells. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7700-5. Epub 2006 May 3. PubMed PMID: 16672370; PubMed Central PMCID: PMC1472508.
Nyström T. Oxidation of bacterial proteome in response to starvation. Methods Biochem Anal. 2006;49:89-95. Review. PubMed PMID: 16929675.
Fredriksson A, Ballesteros M, Dukan S, Nyström T. Induction of the heat shock regulon in response to increased mistranslation requires oxidative modification of the malformed proteins. Mol Microbiol. 2006 Jan;59(1):350-9. PubMed PMID:16359340.
Maisnier-Patin S, Roth JR, Fredriksson A, Nyström T, Berg OG, Andersson DI. Genomic buffering mitigates the effects of deleterious mutations in bacteria. Nat Genet. 2005 Dec;37(12):1376-9. Epub 2005 Nov 6. PubMed PMID: 16273106.
Nachin L, Nannmark U, Nyström T. Differential roles of the universal stress proteins of Escherichia coli in oxidative stress resistance, adhesion, and motility. J Bacteriol. 2005 Sep;187(18):6265-72. PubMed PMID: 16159758; PubMed Central PMCID: PMC1236625.
Fredriksson A, Ballesteros M, Dukan S, Nyström T. Defense against protein carbonylation by DnaK/DnaJ and proteases of the heat shock regulon. J Bacteriol. 2005 Jun;187(12):4207-13. PubMed PMID: 15937182; PubMed Central PMCID: PMC1151714.
Magnusson LU, Farewell A, Nyström T. ppGpp: a global regulator in Escherichia coli. Trends Microbiol. 2005 May;13(5):236-42. Review. PubMed PMID: 15866041.
Nyström T. Role of oxidative carbonylation in protein quality control and senescence. EMBO J. 2005 Apr 6;24(7):1311-7. Epub 2005 Mar 3. Review. PubMed PMID: 15775985; PubMed Central PMCID: PMC1142534.
Johansson E, Olsson O, Nyström T. Progression and specificity of protein oxidation in the life cycle of Arabidopsis thaliana. J Biol Chem. 2004 May 21;279(21):22204-8. Epub 2004 Apr 7. PubMed PMID: 15070894.
Aertsen A, Vanoirbeek K, De Spiegeleer P, Sermon J, Hauben K, Farewell A, Nyström T, Michiels CW. Heat shock protein-mediated resistance to high hydrostatic pressure in Escherichia coli. Appl Environ Microbiol. 2004. May;70(5):2660-6. PubMed PMID: 15128516; PubMed Central PMCID: PMC404417.
Nyström T. Stationary-phase physiology. Annu Rev Microbiol. 2004;58:161-81. Review. PubMed PMID: 15487934.
Prytz I, Sandén AM, Nyström T, Farewell A, Wahlström A, Förberg C, Pragai Z, Barer M, Harwood C, Larsson G. Fed-batch production of recombinant beta-galactosidase using the universal stress promoters uspA and uspB in high cell density cultivations. Biotechnol Bioeng. 2003 Sep 5;83(5):595-603. PubMed PMID: 12827701.
Goksör M, Diez A, Enger J, Hanstorp D, Nyström T. Analysis of molecular diffusion in ftsK cell-division mutants using laser surgery. EMBO Rep. 2003. Sep;4(9):867-71. Epub 2003 Aug 8. PubMed PMID: 12947413; PubMed Central PMCID: PMC1326354.
Mergulhão FJ, Monteiro GA, Larsson G, Bostrom M, Farewell A, Nyström T, Cabral JM, Taipa MA. Evaluation of inducible promoters on the secretion of a ZZ-proinsulin fusion protein in Escherichia coli. Biotechnol Appl Biochem. 2003. Aug;38(Pt 1):87-93. PubMed PMID: 12740005.
Nyström T. The free-radical hypothesis of aging goes prokaryotic. Cell Mol Life Sci. 2003 Jul;60(7):1333-41. Review. PubMed PMID: 12943222.
Hlavatá L, Aguilaniu H, Pichová A, Nyström T. The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS. EMBO J. 2003 Jul 1;22(13):3337-45. Erratum in: EMBO J. 2003 Sep 1;22(17):4577. PubMed PMID: 12839995; PubMed Central PMCID: PMC165639.
Mergulhão FJ, Monteiro GA, Larsson G, Sandén AM, Farewell A, Nystrom T, Cabral JM, Taipa MA. Medium and copy number effects on the secretion of human proinsulin in Escherichia coli using the universal stress promoters uspA and uspB. Appl Microbiol Biotechnol. 2003 Jun;61(5-6):495-501. Epub 2003 Feb 20. PubMed PMID: 12764564.
Kvint K, Nachin L, Diez A, Nyström T. The bacterial universal stress protein: function and regulation. Curr Opin Microbiol. 2003 Apr;6(2):140-5. Review. PubMed PMID: 12732303.
Desnues B, Cuny C, Grégori G, Dukan S, Aguilaniu H, Nyström T. Differential oxidative damage and expression of stress defence regulons in culturable and non-culturable Escherichia coli cells. EMBO Rep. 2003 Apr;4(4):400-4. PubMed PMID: 12671690; PubMed Central PMCID: PMC1319155.
Nyström T. Conditional senescence in bacteria: death of the immortals. Mol Microbiol. 2003 Apr;48(1):17-23. Review. PubMed PMID: 12657042.
Aguilaniu H, Gustafsson L, Rigoulet M, Nyström T. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science. 2003 Mar 14;299(5613):1751-3. Epub 2003 Feb 27. PubMed PMID: 12610228.
Nyström T. Nonculturable bacteria: programmed survival forms or cells at death's door? Bioessays. 2003 Mar;25(3):204-11. Review. PubMed PMID: 12596224.
Sandén AM, Prytz I, Tubulekas I, Förberg C, Le H, Hektor A, Neubauer P, Pragai Z, Harwood C, Ward A, Picon A, De Mattos JT, Postma P, Farewell A, Nyström T, Reeh S, Pedersen S, Larsson G. Limiting factors in Escherichia coli fed-batch production of recombinant proteins. Biotechnol Bioeng. 2003 Jan 20;81(2):158-66. PubMed PMID: 12451552.
Laurie AD, Bernardo LM, Sze CC, Skarfstad E, Szalewska-Palasz A, Nyström T, Shingler V. The role of the alarmone (p)ppGpp in sigma N competition for core RNA polymerase. J Biol Chem. 2003 Jan 17;278(3):1494-503. Epub 2002 Nov 5. PubMed PMID: 12421818.
Magnusson LU, Nystrom T, Farewell A. Underproduction of sigma 70 mimics a stringent response. A proteome approach. J Biol Chem. 2003 Jan 10;278(2):968-73. Epub 2002 Nov 5. PubMed PMID: 12421813.
Hlavatá L, Nyström T. Ras proteins control mitochondrial biogenesis and function in Saccharomyces cerevisiae. Folia Microbiol (Praha). 2003;48(6):725-30. Review. PubMed PMID: 15058183.
Nyström T. Aging in bacteria. Curr Opin Microbiol. 2002 Dec;5(6):596-601. Review. PubMed PMID: 12457704.
Puskárová A, Ferianc P, Kormanec J, Homerová D, Farewell A, Nyström T. Regulation of yodA encoding a novel cadmium-induced protein in Escherichia coli. Microbiology. 2002 Dec;148(Pt 12):3801-11. PubMed PMID: 12480884.
Nyström T. Translational fidelity, protein oxidation, and senescence: lessons from bacteria. Ageing Res Rev. 2002 Sep;1(4):693-703. Review. PubMed PMID:12208238.
Jishage M, Kvint K, Shingler V, Nyström T. Regulation of sigma factor competition by the alarmone ppGpp. Genes Dev. 2002 May 15;16(10):1260-70. PubMed PMID: 12023304; PubMed Central PMCID: PMC186289.
Diez AA, Tunlid A, Nyström T. The Escherichia coli ftsK1 mutation attenuates the induction of sigma(S)-dependent genes upon transition to stationary phase. FEMS Microbiol Lett. 2002 Jan 2;206(1):19-23. PubMed PMID: 11786251.
Gustavsson N, Diez A, Nyström T. The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage. Mol Microbiol. 2002 Jan;43(1):107-17. PubMed PMID: 11849540.
Aguilaniu H, Gustafsson L, Rigoulet M, Nyström T. Protein oxidation in G0 cells of Saccharomyces cerevisiae depends on the state rather than rate of respiration and is enhanced in pos9 but not yap1 mutants. J Biol Chem. 2001 Sep 21;276(38):35396-404. Epub 2001 Jun 28. PubMed PMID: 11431467.
Ballesteros M, Fredriksson A, Henriksson J, Nyström T. Bacterial senescence: protein oxidation in non-proliferating cells is dictated by the accuracy of the ribosomes. EMBO J. 2001 Sep 17;20(18):5280-9. PubMed PMID: 11566891; PubMed Central PMCID: PMC125621.
Nyström T. Not quite dead enough: on bacterial life, culturability, senescence, and death. Arch Microbiol. 2001 Sep;176(3):159-64. Review. PubMed PMID: 11511862.
Ericsson M, Hanstorp D, Hagberg P, Enger J, Nyström T. Sorting out bacterial viability with optical tweezers. J Bacteriol. 2000 Oct;182(19):5551-5. PubMed PMID: 10986260; PubMed Central PMCID: PMC111000.
Diez A, Gustavsson N, Nyström T. The universal stress protein A of Escherichia coli is required for resistance to DNA damaging agents and is regulated by a RecA/FtsK-dependent regulatory pathway. Mol Microbiol. 2000. Jun;36(6):1494-503. PubMed PMID: 10931298.
Dukan S, Farewell A, Ballesteros M, Taddei F, Radman M, Nyström T. Protein oxidation in response to increased transcriptional or translational errors. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5746-9. PubMed PMID: 10811907; PubMed Central PMCID: PMC18504.
Kvint K, Farewell A, Nyström T. RpoS-dependent promoters require guanosine tetraphosphate for induction even in the presence of high levels of sigma(s). J Biol Chem. 2000 May 19;275(20):14795-8. PubMed PMID: 10747855.
Kvint K, Hosbond C, Farewell A, Nybroe O, Nyström T. Emergency derepression: stringency allows RNA polymerase to override negative control by an active repressor. Mol Microbiol. 2000 Jan;35(2):435-43. PubMed PMID: 10652104.
Dukan S, Nyström T. Oxidative stress defense and deterioration of growth-arrested Escherichia coli cells. J Biol Chem. 1999 Sep 10;274(37):26027-32. PubMed PMID: 10473549.
Nyström T. Starvation, cessation of growth and bacterial aging. Curr Opin Microbiol. 1999 Apr;2(2):214-9. Review. PubMed PMID: 10322166.
Farewell A, Kvint K, Nyström T. uspB, a new sigmaS-regulated gene in Escherichia coli which is required for stationary-phase resistance to ethanol. J Bacteriol. 1998 Dec;180(23):6140-7. PubMed PMID: 9829921; PubMed Central PMCID: PMC107697.
Dukan S, Nyström T. Bacterial senescence: stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon. Genes Dev. 1998 Nov 1;12(21):3431-41. PubMed PMID: 9808629; PubMed Central PMCID: PMC317226.
Carlsson A, Nyström T, de Cock H, Bennich H. Attacin--an insect immune protein--binds LPS and triggers the specific inhibition of bacterial outer-membrane protein synthesis. Microbiology. 1998 Aug;144 ( Pt 8):2179-88. PubMed PMID: 9720039.
Farewell A, Kvint K, Nyström T. Negative regulation by RpoS: a case of sigma factor competition. Mol Microbiol. 1998 Aug;29(4):1039-51. PubMed PMID: 9767572.
Nyström T, Gustavsson N. Maintenance energy requirement: what is required for stasis survival of Escherichia coli? Biochim Biophys Acta. 1998 Jun 10;1365(1-2):225-31. Review. PubMed PMID: 9693738.
Ferianc P, Farewell A, Nyström T. The cadmium-stress stimulon of Escherichia coli K-12. Microbiology. 1998 Apr;144 ( Pt 4):1045-50. PubMed PMID: 9579078.
DiRusso CC, Nyström T. The fats of Escherichia coli during infancy and old age: regulation by global regulators, alarmones and lipid intermediates. Mol Microbiol. 1998 Jan;27(1):1-8. Review. PubMed PMID: 9466250.
Freestone P, Nyström T, Trinei M, Norris V. The universal stress protein, UspA, of Escherichia coli is phosphorylated in response to stasis. J Mol Biol. 1997 Dec 5;274(3):318-24. PubMed PMID: 9405142.
Diez AA, Farewell A, Nannmark U, Nyström T. A mutation in the ftsK gene of
Escherichia coli affects cell-cell separation, stationary-phase survival, stress
adaptation, and expression of the gene encoding the stress protein UspA. J
Bacteriol. 1997 Sep;179(18):5878-83. PubMed PMID: 9294448; PubMed Central PMCID:
PMC179480.
Farewell A, Diez AA, DiRusso CC, Nyström T. Role of the Escherichia coli FadR regulator in stasis survival and growth phase-dependent expression of the uspA, fad, and fab genes. J Bacteriol. 1996 Nov;178(22):6443-50. PubMed PMID: 8932299; PubMed Central PMCID: PMC178529.
Nyström T, Larsson C, Gustafsson L. Bacterial defense against aging: role of the Escherichia coli ArcA regulator in gene expression, readjusted energy flux and survival during stasis. EMBO J. 1996 Jul 1;15(13):3219-28. PubMed PMID: 8670822; PubMed Central PMCID: PMC451874.
Nyström T, Neidhardt FC. Effects of overproducing the universal stress protein, UspA, in Escherichia coli K-12. J Bacteriol. 1996 Feb;178(3):927-30. PubMed PMID: 8550536; PubMed Central PMCID: PMC177748.
Nyström T. Glucose starvation stimulon of Escherichia coli: role of integration host factor in starvation survival and growth phase-dependent protein synthesis. J Bacteriol. 1995 Oct;177(19):5707-10. PubMed PMID: 7559363; PubMed Central PMCID: PMC177385.
Nyström T. The trials and tribulations of growth arrest. Trends Microbiol. 1995 Apr;3(4):131-6. Review. PubMed PMID: 7613753.
Nyström T. The glucose-starvation stimulon of Escherichia coli: induced and repressed synthesis of enzymes of central metabolic pathways and role of acetyl phosphate in gene expression and starvation survival. Mol Microbiol. 1994 Jun;12(5):833-43. PubMed PMID: 8052134.
Albertson NH, Nyström T. Effects of starvation for exogenous carbon on functional mRNA stability and rate of peptide chain elongation in Escherichia coli. FEMS Microbiol Lett. 1994 Apr 1;117(2):181-7. PubMed PMID: 8181721.
Nyström T, Neidhardt FC. Expression and role of the universal stress protein, UspA, of Escherichia coli during growth arrest. Mol Microbiol. 1994. Feb;11(3):537-44. PubMed PMID: 8152377.
Nyström T, Neidhardt FC. Isolation and properties of a mutant of Escherichia coli with an insertional inactivation of the uspA gene, which encodes a universal stress protein. J Bacteriol. 1993 Jul;175(13):3949-56. PubMed PMID: 8391533; PubMed Central PMCID: PMC204822.
Nyström T, Neidhardt FC. Cloning, mapping and nucleotide sequencing of a gene encoding a universal stress protein in Escherichia coli. Mol Microbiol. 1992. Nov;6(21):3187-98. PubMed PMID: 1453957.