PEOPLE IN THE LAB
Professor, Principal Investigator
Thomas received his PhD in Microbiology at the University of Gothenburg in 1989 under the supervision of Staffan Kjelleberg working on the topic of how bacteria survive a conditionally induced, growth-arrested, G0–like state. He continued studying this topic under the mentorship of Frederick C. Neidhardt at the University of Michigan, as a postdoctoral fellow. With Fred, he discovered, cloned, and characterized the gene/protein called the Universal Stress Protein A (UspA). Upon returning to Sweden, as an Assistant Professor at Lund University, he demonstrated that the global re-routing of the transcriptional apparatus during cellular growth arrest was governed by a trade-off mechanism, now called sigma factor competition. His work on a bacterial G0-like state also lead to the discovery that aberrant and slightly misfolded proteins are more susceptible to attack by reactive oxygen species, which pinpointed an up-till-then unknown pathway for protein oxidation and established E. coli as a model system for studying the mechanisms underlying oxidative attack to proteins in the context of chronological cellular aging. Upon expanding the studies of protein oxidation to other model systems, the laboratory discovered that oxidatively damage proteins are inherited in a asymmetrical fashion in S. cerevisiae - Specifically, damaged proteins are retained in old mother cells during cytokinesis allowing proteomic age characteristics to be reset in the cellular progeny. Thomas is a Member of the Royal Swedish Academy of Sciences, Class VI, the American Academy of Microbiology, the American Society for Biochemistry and Molecular Biology, and EMBO.
Xinxin is a technician in the TN lab since 2009, and has been involved in establishing a novel high-content imaging based screening approach in the group. She is involved in most of the ongoing projects in the group by providing her experimental expertise, and she also works on updating and maintaining good protocols for the various genome-wide screening techniques used in the lab.
Per did his PhD with Prof. Trisha Davis at the University of Washington in Seattle, WA, USA studying cell division and chromosome segregation. He moved on to a Post-Doc with Director Tony Hyman at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden, Germany where he worked on regulation of microtubule dynamics. Currently, he is working on the role of membrane trafficking in aggregate inclusion formation.
Lisa Larsson Berglund
Lisa recently finished her PhD studies in Thomas Nyström's lab. She studied the role of the actin cytoskeleton in yeast protein quality control with special focus on the segregation of damaged proteins during cell division and the management of wild type huntingtin. Lisa has a new found interest in running and enjoys spending time with family and friends.
Rebecca is a PhD student in the Nyström lab, working on the mechanisms governing aggregation of misfolded proteins and clearance of aggregated proteins. Besides spending time in the lab, Rebecca is spending a lot of time in the gym, competing in powerlifting.
Rebecca is a PhD student in the Nyström lab where she is investigating temporal and spatial protein quality control mechanisms in yeast and mammalian haematopoietic stem cells. Outside of the lab she enjoys Lindy Hop dancing and playing video games.
Kanika did her PhD at Institute of Genomics and Integrative Biology, New Delhi, India. Her PhD work aimed at understanding the role of chemical chaperones in buffering genetic mutations. She is currently investigating the influence of metabolic alteration on proteostasis capacity of ageing cells. When not in the lab she loves to explore nature and capture it through her lens.
Arthur did his PhD at the University of Konstanz in Germany. He worked on the aging/cancer field and investigated how the human tumor suppressor p53 is post-translationally modified by PARP1. He is currently investigating the process of aggregegation of misfolded proteins during aging in yeast. In his free time he loves to do windsurfing and sailing.
Roja did her PhD in Hohmann’s lab at the University of Gothenburg, investigating mechanisms that control the yeast HOG signaling pathway in response to hyperosmotic stress. Currently, she is looking into involvement of the vesicle mediated protein transport pathway as well as COG complex in aggregate inclusion formation.
Doryaneh did her PhD in Prof. Hohmann’s lab at the University of Gothenburg, on the regulation of aquaglyceroporins and the robustness and interconnectivity within the signal transduction pathways. She then did her first postdoc in the Biophotonics group, inventing a lab-on-a-chip approach for elevating arsenite uptake in yeast. She later held a research position in the same group, studying the role of aquaporins in metastatic potential of ovarian cancer cells. Currently, she is looking into the ER-Golgi trafficking and the involvement in clearing protein damage.
Srishti did her PhD in Prof. Alok Mondal's lab at CSIR-Institute of Microbial Technology-Jawahar lal Nehru University in India. Her doctoral thesis is about molecular genetics and structure functional significance of Serine threonine phophatases from a halotolerant yeast Debaryomyces hansenii. She then studied calcium streaming in pathogenic Candida albicans utilizing GECIs at University of Aberdeen, Scotland with Dr Alexandra Brand's group. She also worked on how obesity influences aging in yeast and generating Biofuels from arrested yeast cells was a part of her work in Florida International University, USA. Besides this she is also working on a collaborative project with Prof. P.K Pati from Guru Nanak Dev University-Amritsar India. This project is about molecular genetic characterization of a halotolerant QTL from Oryza sativa, in budding yeast Saccharomyces cerevisiae. Currently, she is interested in calcium dynamics during Proteostasis and how calcium effects PQC machinery and aggregate formation during aging in yeast
The Nyström group in April of 2019.